George Mathis was a printmaker and painter'

Much of Mathis' childhood was spent indoors due to ailments stemming from Pagett's disease; this led to his early interest and self taught pursuit of art. After high school graduation, Mathis attended Washington State University.

Mathis studied landscape painting under William T. McDermott, and the subject would remain his primary theme throughout his career. His artistic career began with commercial art, and he occasionally traded art for everyday goods and services. Mathis' art interests included photography, drawing, and painting at the time. He did not pursue printmaking until 1948, when he and his wife Jean moved to Nevada City, California. There, he opened a successful lithography studio, as well as a gallery that he and Jean ran together.

His prolific career included illustration work for the Aerojet Corporation in Sacramento, where he became known for his depictions of space, sketching the Gemini and Apollo space missions. 

The George Mathis Photo and Art Collection is held by the Manuscripts, Archives, and Special Collections, Washington State University Libraries, in Pullman, Washington.